Serotonin-1a receptors don’t usually down-regulate in respose to increased serotonin 🧠

in contrast to dopamine receptors, the postsynaptic serotonin-1a receptors don’t usually down-regulate in response to increased serotonin. These neurons possess two special characteristics that keep our serotonin neurons and receptors resilient. This is because:

• Serotonin-1a autoreceptors on the dorsal raphe nucleus ensure that it releases a balanced amount of serotonin
• Serotonin-1a receptors inhibit postsynaptic neurons

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References

• Lustig, H., Robert. The Hacking of the American Mind Chapter 10. Self-Inflicted Misery The Dopamine-Cortisol-Serotonin Connection (Location 1924). New York, NY: Penguin Random House.

Metadata

Type:🔴 Tags: Biology / Neuroscience / Biochemistry / Neurochemistry Status:☀️