Serotonin-1a autoreceptors on the dorsal raphe nucleus ensure that it releases a balanced amount of serotonin 🧠

Serotonin neurons in the dorsal raphe nucleus possess an extra control system: they express a set of serotonin-1a autoreceptors on the presynaptic side. By preventing these neurons from firing too rapidly, these autoreceptors make sure the serotonin neurons don’t wear out; and there is rarely enough serotonin in the synapse to down-regulate those-1a autoreceptors.

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