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Serotonin-1a autoreceptors on the dorsal raphe nucleus ensure that it releases a balanced amount of serotonin. SSRIs work by turn those autoreceptors off; it’s like setting the temperature threshold on your servo-mechanism thermostat much higher, and those serotonin nerve terminals fire more serotonin; thus the antidepressant effects.
The physical side effects of SSRIs may cause insomnia, sexual dysfunction, headaches, gastrointestinal problems, dizziness, tremors, nervousness, muscle cramps, muscle weakness, seizures, and a severe inner agitation known as akathisia, which is associated with an increased risk of violence and suicide.
References
- Whitaker, Robert. (2010). Anatomy of an Epidemic Chapter 11 The Epidemic Spreads to Children (Epub p. 317). New York , NY: Crown Publishing.
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