Insulin resistance leads to an imbalace of ghrelin with insulin and leptin

When insulin is low and working right, both insulin and leptin counterbalance ghrelin and keep you weight-stable. But when you become insulin resistant, the leptin signal is blocked—now the ghrelin runs things, so you’re hungrier and storing like crazy. Therefore, the prime directive of metabolic therapy is “get the insulin down.” And that’s true, regardless of your weight.

---

References

• Lustig, Robert. (2021). Metabolical Chapter 2. “Modern Medicine” Treats Symptoms, Not Disease (p. 40). New York, NY: HarperCollins Publishers.

Metadata

Type:🔴 Tags: Biology / Biochemistry Status:☀️